2. Academic Validation
  3. 1,2,3,4,6-Penta-O-galloyl-β-d-glucose suppresses colon cancer through induction of tumor suppressor

1,2,3,4,6-Penta-O-galloyl-β-d-glucose suppresses colon cancer through induction of tumor suppressor

  • Bioorg Med Chem Lett. 2018 Jul 1;28(12):2117-2123. doi: 10.1016/j.bmcl.2018.05.028.
Sang Hee Kawk 1,  Ye Rim Kang 2,  Yoon Hee Kim 3
Affiliations

Affiliations

  • 1 Department of Food and Nutrition, College of Engineering, Daegu University, Gyeongsan 38453, Republic of Korea. Electronic address: tummy1218@naver.com.
  • 2 Department of Food and Nutrition, College of Engineering, Daegu University, Gyeongsan 38453, Republic of Korea. Electronic address: mmkil63@hanmail.net.
  • 3 Department of Food and Nutrition, College of Engineering, Daegu University, Gyeongsan 38453, Republic of Korea; Research Institute of Anti-aging, Daegu University, Gyeongsan 38453, Republic of Korea. Electronic address: kimyh0128@daegu.ac.kr.
PMID: 29778287 DOI: 10.1016/j.bmcl.2018.05.028
Abstract

Colon Cancer is the third most common malignancy in both sexes of Korea. Here, we investigated anti-colorectal Cancer effects of 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG), a gallotannin from Galla rhois, and its possible mechanisms. PGG induced cytotoxicity and decreased proliferation of colon Cancer cells without affecting normal colon fibroblasts. PGG inhibited clonogenic ability and induced Apoptosis in Cancer cells. One of the underlying mechanisms of the anti-cancer effect exerted by PGG, was owing to the induction p53 expression, a well-known tumor suppressor, and increased in P21, the representative target gene of p53. PGG affected cell-cycle- or apoptosis-related proteins such as cyclin E, CDK2, and Bcl-2, cleaved Caspase-3. Also, PGG induced Caspase-3/7 activity. These data suggest that PGG exerts anti-colorectal Cancer effects.

Keywords

Anti-cancer effect; Bioactive compound; Colon cancer; P53; PGG.

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