2. Academic Validation
  3. Alkaloids from Melodinus henryi with anti-inflammatory activity

Alkaloids from Melodinus henryi with anti-inflammatory activity

  • J Asian Nat Prod Res. 2019 Aug;21(8):820-825. doi: 10.1080/10286020.2018.1482878.
Jin-Qian Yu 1,  Xiao-Wei Sun 2,  Zhi-Wei Wang 1,  Lei Fang 3,  Xiao Wang 1 2
Affiliations

Affiliations

  • 1 a Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center , Qilu University of Technology (Shandong Academy of Sciences) , Jinan 250014 , China.
  • 2 b School of Chemistry and Pharmaceutical Engineering , Qilu University of Technology , Jinan 250014 , China.
  • 3 c College of Biological Sciences and Technology , University of Jinan , Jinan 250022 , China.
PMID: 29933711 DOI: 10.1080/10286020.2018.1482878
Abstract

One new quinolinic scandine-type monoterpeniod alkaloid, 3-oxo-scandine (1), as well as seven known ones (2-8), was isolated from the roots of Melodinus henryi. Their structures were elucidated by extensive spectroscopic analysis. All of the compounds were prepared and evaluated for their anti-inflammatory activities by measuring the inhibitory activity of nitric oxide (NO) in vitro in RAW 264.7 mouse peritoneal macrophages. Compounds 6 and 7 showed significant activities with IC50 values of 8.54 and 5.19 μM, respectively.

Keywords

Apocynaceae; anti-inflammatory activity; isolation; monoterpeniod alkaloid.

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