Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen - A new hybrid design paradigm

Affiliations

• 1 Department of Chemistry, McGill University, 801 Sherbrooke W., Montreal, QC H3A 0B8, Canada.
• 2 Institute for Research in Immunology and Cancer, Pavillon Marcelle-Coutu, Université de Montréal, 2950 chemin de Polytechnique, Montréal, QC H3T 1J4, Canada.
• 3 Institute for Research in Immunology and Cancer, Pavillon Marcelle-Coutu, Université de Montréal, 2950 chemin de Polytechnique, Montréal, QC H3T 1J4, Canada; Biochemistry Department, Pavillon Roger-Gaudry, Université de Montréal, 2900 Bd Edouard Montpetit, Montréal, QC H3T 1J4, Canada; Centre de Recherche du CHUM, Université de Montréal, Montréal, QC H2X 0A9, Canada.
• 4 Department of Chemistry, McGill University, 801 Sherbrooke W., Montreal, QC H3A 0B8, Canada. Electronic address: jim.gleason@mcgill.ca.