2. Academic Validation
  3. Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species

  • J Nat Prod. 2018 Aug 24;81(8):1884-1891. doi: 10.1021/acs.jnatprod.8b00411.
Misa Takeuchi 1,  Yohei Saito 1,  Masuo Goto 2,  Katsunori Miyake 3,  David J Newman 4,  Barry R O'Keefe 5 6,  Kuo-Hsiung Lee 2 7,  Kyoko Nakagawa-Goto 1 2
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences , Kanazawa University , Kanazawa , 920-1192 , Japan.
  • 2 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7568 , United States.
  • 3 Tokyo University of Pharmacy and Life Sciences , Hachioji , Tokyo 192-0392 , Japan.
  • 4 NIH Special Volunteer , Wayne , Pennsylvania 19087 , United States.
  • 5 Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute , NCI at Frederick , Frederick , Maryland 21702-1201 , United States.
  • 6 Molecular Targets Program, Center for Cancer Research, National Cancer Institute , NCI at Frederick , Frederick , Maryland 21702-1201 , United States.
  • 7 Chinese Medicine Research and Development Center , China Medical University and Hospital , 2 Yuh-Der Road , Taichung , 40447 , Taiwan.
PMID: 30106296 DOI: 10.1021/acs.jnatprod.8b00411
Abstract

Alangium longiflorum is currently in extinction crisis, which will likely severely hamper further phytochemical investigation of this plant species from new collections. A crude extract of leaves of A. longiflorum (N33539), collected for the U.S. National Cancer Institute in 1989, showed potent Cancer cell line antiproliferative activity. A phytochemical study resulted in the isolation of 17 secondary metabolites, including two new tetrahydroisoquinoline Alkaloids, 8-hydroxytubulosine (1) and 2'- O- trans-sinapoylisoalangiside (2), as well as a new sinapolyloxylupene derivative (3). Using in-house assays and NCI-60 panel screening, compound 1 displayed broad-spectrum inhibitory activity at submicromolar levels against most tested tumor cell lines, except for drug-transporter-overexpressing cells. Compound 1 caused accumulation of sub-G1 cells with no effect on cell cycle progression, suggesting that this substance is an Apoptosis inducer.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z