2. Academic Validation
  3. Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

  • Medchemcomm. 2016 Nov 15;8(1):198-201. doi: 10.1039/c6md00493h.
Weining Niu 1,  Ping Wu 1,  Fei Chen 1,  Jun Wang 1,  Xiaoya Shang 1,  Chunlan Xu 1
Affiliations

Affiliation

  • 1 Key Laboratory for Space Bioscience and Space Biotechnology , School of Life Sciences , Northwestern Polytechnical University , Xi'an , 710072 , China . Email: niuweining@nwpu.edu.cn.
PMID: 30108705 DOI: 10.1039/c6md00493h
Abstract

A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key Enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 Cancer cells, with IC50 values of less than 10 μM.

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