2. Academic Validation
  3. Antiproliferative Sesquiterpenoids from Ligularia rumicifolia with Diverse Skeletons

Antiproliferative Sesquiterpenoids from Ligularia rumicifolia with Diverse Skeletons

  • J Nat Prod. 2018 Sep 28;81(9):1992-2003. doi: 10.1021/acs.jnatprod.8b00197.
Ye Ye 1 2,  Drolma Dawa 3,  Guang-Hui Liu 1 2,  Min Zhao 1,  Dorje Tseden 3,  Yu-Cheng Gu 4,  Li-Sheng Ding 1,  Zhi-Xing Cao 5,  Yan Zhou 1
Affiliations

Affiliations

  • 1 Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 , People's Republic of China.
  • 2 University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
  • 3 Tibet Autonomous Region Institute for Food and Drug Control , Lhasa 850000 , People's Republic of China.
  • 4 Syngenta Jealott's Hill International Research Centre, Berkshire RG42 6EY , U.K.
  • 5 Pharmacy College , Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , People's Republic of China.
PMID: 30212198 DOI: 10.1021/acs.jnatprod.8b00197
Abstract

Twenty-two new sesquiterpenoids with four skeletal types and 15 known analogues were isolated from the whole Plants of Ligularia rumicifolia. The structures of the isolates were elucidated based on comprehensive spectroscopic data analysis. Compound 1 is a C14 nor-sesquiterpenoid featuring a 6/6/6 tricyclic skeleton with a 9,13-ether bridge. The absolute configuration of 2 was established through single-crystal X-ray diffraction data. Compounds 13-16 exhibited in vitro antiproliferative activity against the four human tumor cell lines A-549, HGC-27, HeLa, and MV4-11. Specifically, compounds 13 and 16 showed antiproliferative activity against the MV4-11 cell line with IC50 values of 0.5 ± 0.2 and 1.1 ± 0.5 μM, respectively.

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