2. Academic Validation
  3. Determination of xanthones and flavonoids of methanol extracts obtained from different parts of the plants of three Gentianaceae species

Determination of xanthones and flavonoids of methanol extracts obtained from different parts of the plants of three Gentianaceae species

  • J Pharm Biomed Anal. 2018 Nov 30;161:455-463. doi: 10.1016/j.jpba.2018.08.059.
Cheng-Yong Feng 1,  Qian Wu 1,  Dan-Dan Yin 1,  Bing Li 1,  Shan-Shan Li 2,  Zhong-Qiu Tang 3,  Yan-Jun Xu 4,  Liang-Sheng Wang 5
Affiliations

Affiliations

  • 1 Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • 2 Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: shshli@ibcas.ac.cn.
  • 3 Forestry and Agricultural Academy of Greater Khingan Mountains, Jiagedaqi 165000, China.
  • 4 College of Science, China Agricultural University, Beijing 100094, China.
  • 5 Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: wanglsh@ibcas.ac.cn.
PMID: 30216794 DOI: 10.1016/j.jpba.2018.08.059
Abstract

Gentianopsis barbata, Halenia corniculata, and Gentianella acuta were widely distributed throughout China and commonly used in traditional Chinese medicine. However, owing to similar living environments and morphological features, locals often had trouble distinguishing between these three species. In this present study, chromatograms at 350 nm were obtained and the composition and content of their chemical compounds determined using HPLC-DAD/ESI-MS2. In total, 35 chemical compounds were detected, 32 of which were identified, 25 of which were Xanthones, 6 Flavonoids, and 1 chlorogenic acid. The 350 nm chromatograms of these three species displayed evident differences. The individual compounds and their occurrence and content in different parts of the plant within different species were included in our results. This basic data will be useful for future pharmacological study. The total compositions of Flavonoids and Xanthones were approximately comparable in G. barbata and H. corniculata. Meanwhile, Xanthones were predominant in G. acuta. From the perspective of chemical compound compositions, the leaf is recommended as the most valuable medicinal section for each of these three species.

Keywords

Flavonoid; Gentianaceae; HPLC; Xanthone.

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