2. Academic Validation
  3. Monodisperse oligoethylene glycols modified Propofol prodrugs

Monodisperse oligoethylene glycols modified Propofol prodrugs

  • Bioorg Med Chem Lett. 2018 Dec 1;28(22):3502-3505. doi: 10.1016/j.bmcl.2018.10.009.
Tao Deng 1,  Xianglan Mao 1,  Yu Li 1,  Shaowei Bo 1,  Zhigang Yang 1,  Zhong-Xing Jiang 2
Affiliations

Affiliations

  • 1 Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
  • 2 Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. Electronic address: zxjiang@whu.edu.cn.
PMID: 30318437 DOI: 10.1016/j.bmcl.2018.10.009
Abstract

The low water solubility of Propofol resulted in complicated formulation and adverse effects during its clinical application. To improve its water solubility and maintain its anesthetic effects, Propofol prodrugs with monodisperse oligoethylene glycols as solubility enhancer were designed and synthesized. Monodisperse oligoethylene glycols enable the concise manipulation of water solubility, biocompatibility and anesthetic effects. Through the physicochemical and biological assay, a few water soluble prodrugs of Propofol were identified as promising anesthetic to overcome the drawbacks associated with Propofol.

Keywords

Anesthetic; Monodisperse; Polyethylene glycols; Prodrug; Propofol.

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