2. Academic Validation
  3. Preussins with Inhibition of IL-6 Expression from Aspergillus flocculosus 16D-1, a Fungus Isolated from the Marine Sponge Phakellia fusca

Preussins with Inhibition of IL-6 Expression from Aspergillus flocculosus 16D-1, a Fungus Isolated from the Marine Sponge Phakellia fusca

  • J Nat Prod. 2018 Oct 26;81(10):2275-2281. doi: 10.1021/acs.jnatprod.8b00662.
Bin-Bin Gu 1,  Fu-Rong Jiao 1,  Wei Wu 1,  Wei-Hua Jiao 1,  Lei Li 1,  Fan Sun 1,  Shu-Ping Wang 1,  Fan Yang 1,  Hou-Wen Lin 1
Affiliations

Affiliation

  • 1 Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai , 200127 , People's Republic of China.
PMID: 30350993 DOI: 10.1021/acs.jnatprod.8b00662
Abstract

New pyrrolidine Alkaloids, preussins C-I (1-7) and (11 R)/(11 S)-preussins J and K (8 and 9), were isolated from the sponge-derived fungus Aspergillus flocculosus 16D-1. The structures and configurations of these preussins were elucidated by detailed spectroscopic analysis, modified Mosher's method, and comparisons with literature data. These compounds showed strong to moderate inhibitory activity toward IL-6 production in lipopolysaccharide-induced THP-1 cells with IC50 values ranging from 0.11 to 22 μM, but were inactive against normal tumor cell lines and fungi.

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