2. Academic Validation
  3. Th17 cell-derived IL-17A promoted tumor progression via STAT3/NF-κB/Notch1 signaling in non-small cell lung cancer

Th17 cell-derived IL-17A promoted tumor progression via STAT3/NF-κB/Notch1 signaling in non-small cell lung cancer

  • Oncoimmunology. 2018 Aug 23;7(11):e1461303. doi: 10.1080/2162402X.2018.1461303.
Ruirui Wang 1 2 3 4,  Li Yang 1 2 3,  Chaoqi Zhang 1 2 3,  Ruijie Wang 1 2 3,  Zhen Zhang 1 2 3,  Qianyi He 1 2 3,  Xinfeng Chen 1 2 3,  Bin Zhang 5,  Zhihai Qin 4,  Liping Wang 2 3,  Yi Zhang 1 2 3 6
Affiliations

Affiliations

  • 1 Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
  • 2 Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
  • 3 Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan 450052, P.R. China.
  • 4 Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
  • 5 Department of Hematology/Oncology, School of Medicine, Northwestern University, Chicago, IL60611, USA.
  • 6 School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
PMID: 30377557 DOI: 10.1080/2162402X.2018.1461303
Abstract

Non-small cell lung Cancer (NSCLC) accounts for the majority of all lung Cancer cases, which is the leading cause of Cancer deaths worldwide. IL-17░A, the major effector cytokine derived from Th17 cells, is a key cytokine in tumor pathogenesis and modulates tumor progression. We aimed to identify whether IL-17░A derived from Th17 cells promotes the progression of NSCLC. Here we found that the level of Th17 cells was increased in NSCLC and IL-17░A was mainly produced by CD4+ cells (Th17 cells) in NSCLC. IL-17░A enhanced the migration, invasion and stemness of NSCLC via STAT3/NF-κB/Notch1 signaling. Blockade of this signaling inhibited the migration, invasion and stemness of NSCLC mediated by IL-17░A. Th17 cells in NSCLC were closely associated with poor prognosis of NSCLC patients. Our results indicated that Th17 cell-derived IL-17░A plays an important role in tumor progression of NSCLC via STAT3/NF-κB/Notch1 signaling. Therefore, therapeutic strategies against this pathway would be valuable to be developed for NSCLC treatment.

Keywords

Th17 cells; Tumor microenvironment; interleukin-17A (IL-17A); non-small cell lung cancer (NSCLC); tumor progression.

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