2. Academic Validation
  3. Nothofagin suppresses mast cell-mediated allergic inflammation

Nothofagin suppresses mast cell-mediated allergic inflammation

  • Chem Biol Interact. 2019 Jan 25;298:1-7. doi: 10.1016/j.cbi.2018.10.025.
Byeong-Cheol Kang 1,  Min-Jong Kim 1,  Soyoung Lee 2,  Young-Ae Choi 1,  Pil-Hoon Park 3,  Tae-Yong Shin 4,  Taeg Kyu Kwon 5,  Dongwoo Khang 6,  Sang-Hyun Kim 7
Affiliations

Affiliations

  • 1 CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
  • 2 Immunoregulatory Materials Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea.
  • 3 College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
  • 4 College of Pharmacy, Woosuk University, Jeonju, Republic of Korea.
  • 5 Department of Immunology, School of Medicine, Keimyung University, Daegu, Republic of Korea.
  • 6 Department of Physiology, School of Medicine, Gachon University, Incheon, Republic of Korea. Electronic address: dkhang@gachon.ac.kr.
  • 7 CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address: shkim72@knu.ac.kr.
PMID: 30392763 DOI: 10.1016/j.cbi.2018.10.025
Abstract

Mast cells play a major role in immunoglobulin E-mediated allergic inflammation, which is involved in asthma, atopic dermatitis, and allergic rhinitis. Nothofagin has been shown to ameliorate various inflammatory responses such as the septic response and vascular inflammation. In this study, we assessed the inhibitory effect of nothofagin on allergic inflammation using cultured/isolated mast cells and an anaphylaxis mouse model. Nothofagin treatment prevented histamine and β-hexosaminidase release by reducing the influx of calcium into the cytosol in a concentration-dependent manner. Nothofagin also inhibited the gene expression and secretion of pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin-4 by downregulating the phosphorylation of Lyn, Syk, Akt and nuclear translocation of nuclear factor-κB. To confirm these effects of nothofagin in vivo, we used a passive cutaneous anaphylaxis mouse model. Topical administration of nothofagin suppressed local pigmentation and ear thickness. Taken together, these results suggest nothofagin as a potential candidate for the treatment of mast cell-involved allergic inflammatory diseases.

Keywords

Allergic inflammation; Histamine; Mast cells; Nothofagin.

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