2. Academic Validation
  3. A novel acylated quercetin glycoside and compounds of inhibitory effects on α-glucosidase from Panax ginseng flower buds

A novel acylated quercetin glycoside and compounds of inhibitory effects on α-glucosidase from Panax ginseng flower buds

  • Nat Prod Res. 2020 Sep;34(18):2559-2565. doi: 10.1080/14786419.2018.1543685.
Keke Li 1,  Shasha Li 2,  Fei Xu 2,  Guiyun Cao 3,  Xiaojie Gong 1
Affiliations

Affiliations

  • 1 Department of Biological Engineering, College of Life Science, Dalian Minzu University, Dalian, People's Republic of China.
  • 2 College of Medical, Dalian University, Dalian, People's Republic of China.
  • 3 Shandong Hongjitang Pharmaceutical Group Co., Ltd., Jinan, People's Republic of China.
PMID: 30450965 DOI: 10.1080/14786419.2018.1543685
Abstract

A novel acylated quercetin glycoside, floralpanasenoside A (1) and five known flavonoid glycosides, panasenoside (2), quercetin 3-O-(2''-β-D-glucopyranosyl)-β-D- galactopyranoside (3), trifolin (4) kaempferol 7-O-α-L-rhamnoside (5), and afzelin (6) were isolated from the flower buds of Panax ginseng. Their structures were established by spectroscopic data and comparison with the literature values. Four of the six isolated compounds including 1 (IC50 = 62.4) exhibited α-glucosidase inhibitory activity with IC50 values lower than acarbose (385.2 μM). The molecular docking study indicated that 1 bound to the active site of α-glucosidase with numerous hydrogen bond interactions.

Keywords

Panax ginseng; acylated quercetin glycoside; flavonoids; floralpanasenoside A; α-glucosidase inhibition.

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