2. Academic Validation
  3. Antiprotozoal Isoprenoids from Salvia hydrangea

Antiprotozoal Isoprenoids from Salvia hydrangea

  • J Nat Prod. 2018 Dec 28;81(12):2682-2691. doi: 10.1021/acs.jnatprod.8b00498.
Marzieh Tabefam 1 2,  Mahdi Moridi Farimani 1,  Ombeline Danton 2,  Justine Ramseyer 2,  Samad Nejad Ebrahimi 1,  Markus Neuburger 3,  Marcel Kaiser 4 5,  Peyman Salehi 1,  Olivier Potterat 2,  Matthias Hamburger 2
Affiliations

Affiliations

  • 1 Department of Phytochemistry, Medicinal Plants and Drugs Research Institute , Shahid Beheshti University , G. C., Evin , Tehran , Iran.
  • 2 Department of Pharmaceutical Biology , University of Basel , Klingelbergstrasse 50 , 4056 Basel , Switzerland.
  • 3 Inorganic Chemistry, Department of Chemistry , University of Basel , Mattenstrasse 24a , 4058 Basel , Switzerland.
  • 4 Swiss Tropical and Public Health Institute , Socinstrasse 57 , 4002 Basel , Switzerland.
  • 5 University of Basel , 4001 Basel , Switzerland.
PMID: 30565934 DOI: 10.1021/acs.jnatprod.8b00498
Abstract

Fractionation of the n-hexane extract of Salvia hydrangea afforded seven isoprenoids including six new compounds (1-6) and salvadione A (7). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS). The absolute configuration of salvadione A (7) was established by single-crystal X-ray diffraction analysis with Cu/Kα radiation. In addition, the absolute configuration of all compounds was determined by electronic circular dichroism spectroscopy. A biosynthetic pathway for the formation of the scaffold of 1 is proposed. The antiprotozoal activity of the compounds against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum was determined, and cytotoxicity was assessed in rat myoblast L6 cells. Perovskone C (2) exhibited good activity against P. falciparum (IC50 0.6 μM) and a selectivity index of 62.2.

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