2. Academic Validation
  3. Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan-induced diabetic mice

Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan-induced diabetic mice

  • Future Med Chem. 2019 Mar;11(5):395-406. doi: 10.4155/fmc-2018-0515.
Lanting Xu 1 2,  Meimei Xing 1 2,  Xiaoqing Xu 2,  Fatma Sa Saadeldeen 2,  Zhenhua Liu 1 2,  Jinfeng Wei 1 2,  Wenyi Kang 1 2
Affiliations

Affiliations

  • 1 National Center for Research & Development of Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China.
  • 2 Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Kaifeng 475004, China.
PMID: 30650995 DOI: 10.4155/fmc-2018-0515
Abstract

Aim: Alizarin (AZ), that can be isolated from Rubia cordifolia, has biological activities such as antioxidation and anti-inflammatory. This study aimed to investigate the effect of AZ on glucose and lipid metabolism disorders in alloxan-induced diabetic mice and also explored the effect of AZ on Insulin resistance in 3T3-L1 adipocytes.

Results: The research showed that AZ could decrease fasting and postprandial blood glucose, TG, TC and MDA, and it could also increase liver glycogen levels and SOD activity in diabetic mice. AZ could significantly improve the glucose uptake of 3T3-L1 adipocytes under Insulin resistance, and could also increase GLUT4 protein expression levels, IRS-1 and Akt protein phosphorylation.

Conclusion: These results showed that AZ has the potential to reduce blood sugar and improve Insulin resistance.

Keywords

3T3-L1; IRS-1/PI3K/Akt; alizarin; diabetes; insulin resistance.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z