2. Academic Validation
  3. Potential Anticancer Agents Characterized from Selected Tropical Plants

Potential Anticancer Agents Characterized from Selected Tropical Plants

  • J Nat Prod. 2019 Mar 22;82(3):657-679. doi: 10.1021/acs.jnatprod.9b00018.
Yulin Ren 1,  Esperanza J Carcache de Blanco 1,  James R Fuchs 1,  Djaja D Soejarto 2 3,  Joanna E Burdette 2,  Steven M Swanson 4,  A Douglas Kinghorn 1
Affiliations

Affiliations

  • 1 Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States.
  • 2 Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60612 , United States.
  • 3 Science and Education, Field Museum of Natural History , Chicago , Illinois 60605 , United States.
  • 4 School of Pharmacy , University of Wisconsin-Madison , Madison , Wisconsin 53705 , United States.
PMID: 30830783 DOI: 10.1021/acs.jnatprod.9b00018
Abstract

Higher Plants are well known for their value in affording clinically useful Anticancer agents, with such compounds acting against Cancer cells by a range of mechanisms of action. There remains a strong interest in the discovery and development of plant secondary metabolites as additional Cancer chemotherapeutic lead compounds. In the present review, progress on the discovery of plant-derived compounds of the biflavonoid, lignan, sesquiterpene, steroid, and xanthone structural types is presented. Several potential Anticancer leads of these types have been characterized from tropical Plants collected in three countries as part of our ongoing collaborative multi-institutional project. Preliminary structure-activity relationships and work on in vivo testing and cellular mechanisms of action are also discussed. In addition, the relevant work reported by Other groups on the same compound classes is included herein.

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