2. Academic Validation
  3. Intestinal Anti-Inflammatory Effect of a Peptide Derived from Gastrointestinal Digestion of Buffalo ( Bubalus bubalis) Mozzarella Cheese

Intestinal Anti-Inflammatory Effect of a Peptide Derived from Gastrointestinal Digestion of Buffalo ( Bubalus bubalis) Mozzarella Cheese

  • Nutrients. 2019 Mar 13;11(3):610. doi: 10.3390/nu11030610.
Gian Carlo Tenore 1,  Ester Pagano 2,  Stefania Lama 3,  Daniela Vanacore 4,  Salvatore Di Maro 5,  Maria Maisto 6,  Raffaele Capasso 7,  Francesco Merlino 8,  Francesca Borrelli 9,  Paola Stiuso 10,  Ettore Novellino 11
Affiliations

Affiliations

  • 1 Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. giancarlo.tenore@unina.it.
  • 2 Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. ester.pagano@unina.it.
  • 3 Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio 7, 80138 Naples, Italy. stefania.lama@unicampania.it.
  • 4 Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio 7, 80138 Naples, Italy. daniela.vanacore@unicampania.it.
  • 5 DiSTABiF, Università degli Studi della Campania "Luigi Vanvitelli", via Vivaldi 43, 81100 Caserta, Italy. salvatore.dimaro@unicampania.it.
  • 6 Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. maria.maisto@unina.it.
  • 7 Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy. raffaele.capasso@unina.it.
  • 8 Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. francesco.merlino@unina.it.
  • 9 Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. franborr@unina.it.
  • 10 Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio 7, 80138 Naples, Italy. paola.stiuso@unicampania.it.
  • 11 Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. ettore.novellino@unina.it.
PMID: 30871183 DOI: 10.3390/nu11030610
Abstract

Under physiological conditions, the small intestine represents a barrier against harmful antigens and pathogens. Maintaining of the intestinal barrier depends largely on cell⁻cell interactions (adherent-junctions) and cell⁻matrix interactions (tight-junctions). Inflammatory bowel disease is characterized by chronic inflammation, which induces a destructuring of the architecture junctional epithelial proteins with consequent rupture of the intestinal barrier. Recently, a peptide identified by Bubalus bubalis milk-derived products (MBCP) has been able to reduce oxidative stress in intestinal epithelial cells and erythrocytes. Our aim was to evaluate the therapeutic potential of MBCP in inflammatory bowel disease (IBD). We studied the effect of MBCP on (i) inflamed human intestinal Caco2 cells and (ii) dinitrobenzene sulfonic acid (DNBS) mice model of colitis. We have shown that MBCP, at non-cytotoxic concentrations, both in vitro and in vivo induced the adherent epithelial junctions organization, modulated the nuclear factor (NF)-κB pathway and reduced the intestinal permeability. Furthermore, the MBCP reverted the atropine and tubocurarine injury effects on adherent-junctions. The data obtained showed that MBCP possesses anti-inflammatory effects both in vitro and in vivo. These results could have an important impact on the therapeutic potential of MBCP in helping to restore the intestinal epithelium integrity damaged by inflammation.

Keywords

bioactive peptides; epithelial adherens junctions; inflammatory bowel disease; intestinal inflammation.

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