2. Academic Validation
  3. Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana

Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana

  • J Asian Nat Prod Res. 2020 Jan;22(1):52-60. doi: 10.1080/10286020.2018.1553958.
Hanita Omar 1 2,  Mehran Fadaeinasab 1 3,  Hairin Taha 4,  Aty Widyawaruyanti 5,  Mohd Azlan Nafiah 6,  Tiah Rachmatiah 7
Affiliations

Affiliations

  • 1 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
  • 2 Centre for Foundation Studies in Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
  • 3 School of Chemical Sciences, University of Science Malaysia, Penang 11800, Malaysia.
  • 4 Institute of Energy Infrastructure, Universiti Tenaga Nasional, Kajang 43000, Malaysia.
  • 5 Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya 60115, Indonesia.
  • 6 Chemistry Department, Faculty of Science and Mathematics, University of Pendidikan Sultan Idris, Tg. Malim, Perak 35900, Malaysia.
  • 7 Department of Chemistry, Faculty of Science and Mathematics, University of Indonesia, Depok 16424, Indonesia.
PMID: 30897964 DOI: 10.1080/10286020.2018.1553958
Abstract

One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3-6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively.

Keywords

Lauraceae; Phoebe tavoyana; Plasmodium falciparum; antiplasmodial; aporphine alkaloid; morphinandienone.

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