2. Academic Validation
  3. The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice

The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice

  • Molecules. 2019 Apr 24;24(8):1617. doi: 10.3390/molecules24081617.
Xiao Zhang 1,  Xing Li 2,  Ning Liu 3,  Ping Zheng 4,  Lin Ma 5,  Fengying Guo 6,  Tao Sun 7,  Ru Zhou 8,  Jianqiang Yu 9 10
Affiliations

Affiliations

  • 1 Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China. zhangxiao5922017@126.com.
  • 2 Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China. lixing5922017@126.com.
  • 3 Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China. liuning234@126.com.
  • 4 Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China. zhengping122@126.com.
  • 5 Ningxia Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan 750004, China. linma492201@126.com.
  • 6 College of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China. 19651210@163.com.
  • 7 Ningxia Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan 750004, China. suntao@126.com.
  • 8 Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China. zhouru@nxmu.edu.cn.
  • 9 Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China. yujqlab@163.com.
  • 10 Ningxia Hui Medicine Modern Engineering Research Center and Collaborative Innovation Center, Ningxia Medical University, Yinchuan 750004, China. yujqlab@163.com.
PMID: 31022879 DOI: 10.3390/molecules24081617
Abstract

Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world. Approximately one-third of the epileptic patients that suffer from seizures do not receive effective medical treatment. The aim of this study was to determine the potential anticonvulsant activities of Baldrinal (BAL) with a mouse model of pilocarpine (PILO)-induced epilepsy. The mice were treated with different doses of BAL or sodium valproate prior to PILO injection. Spontaneous and evoked seizures were evaluated from EEG recordings, and their severity was tested by the Racine scale. In addition, the brain tissues were analyzed for histological changes, and the in situ levels of glutamic acid (Glu) and gamma-aminobutyric acid (GABA) were also measured. Activation of astrocytes in the hippocampus was measured. PILO-treated mice showed a significant increase in Glu levels, which was restored by BAL. In addition, BAL treatment also reduced the rate of seizures in the epileptic mice, and ameliorated the increased levels of NMDAR1, BDNF, IL-1β and TNF-α. Taken together, BAL has a potential antiepileptic effect, which may be mediated by reducing the inflammatory response in the PILO-induced brain and restoring the balance of GABAergic and glutamatergic neurons.

Keywords

Baldrinal; anticonvulsant; astrocytes; neuroprotective; neurotransmitter; pilocarpine; γ-aminobutyric acid.

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