2. Academic Validation
  3. Prenylated Acylphloroglucinols from Hypericum faberi

Prenylated Acylphloroglucinols from Hypericum faberi

  • J Nat Prod. 2019 May 24;82(5):1367-1371. doi: 10.1021/acs.jnatprod.8b01006.
Xin-Wen Zhang 1 2,  Shao-Qiang Fan 3,  Fan Xia 1 2,  Yan-Song Ye 1 2,  Xing-Wei Yang 1,  Xian-Wen Yang 3,  Gang Xu 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.
  • 2 University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
  • 3 Key Laboratory of Marine Biogenetic Resources , Third Institute of Oceanography , 184 Daxue Road , Xiamen 361005 , People's Republic of China.
PMID: 31042380 DOI: 10.1021/acs.jnatprod.8b01006
Abstract

The isolation and structure elucidation of six new prenylated acylphloroglucinols, faberiones A-F, from the whole plant of Hypericum faberi is reported. Faberiones A-D (1-4) share a rare styrene substituent and may be biosynthetically generated via further acylation of the acylphloroglucinols. By analyzing the MS and NMR data, the structures of the new isolates were established. Faberiones B (2) and C (3) showed moderate cytotoxicity against the pancreatic cell line (PANC-1) with IC50 values of 6.2 and 9.0 μM, respectively.

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