2. Academic Validation
  3. Sesquiterpenes from an Endophytic Aspergillus flavus

Sesquiterpenes from an Endophytic Aspergillus flavus

  • J Nat Prod. 2019 May 24;82(5):1063-1071. doi: 10.1021/acs.jnatprod.8b01084.
Zhen Liu 1,  Jing-Yi Zhao 1,  Sen-Feng Sun 1,  Yong Li 1,  Jing Qu 1,  Hai-Tao Liu 2,  Yun-Bao Liu 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
  • 2 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education , Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing 100193 , People's Republic of China.
PMID: 31050424 DOI: 10.1021/acs.jnatprod.8b01084
Abstract

Eight new cadinene-sesquiterpenes (1-8), one eudesmane-sesquiterpene (9), and three known compounds (10-13) were isolated from an endophytic fungus, Aspergillus flavus, which was isolated from a toxic medicinal plant, Tylophora ovata. Their structures were elucidated by interpretation of spectroscopic data, and absolute configurations determined according to the specific rotation and electron circular dichroism methods. Compounds 4-8, 11, and 12 exhibited latent hepatic protection effects at 10 μM, and compound 12 selectively inhibited the proliferation of MCF-7 breast Cancer cells with an IC50 values of 2.6 μM.

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