2. Academic Validation
  3. Studies on WF-3681, a novel aldose reductase inhibitor. II. Structure determination and synthesis

Studies on WF-3681, a novel aldose reductase inhibitor. II. Structure determination and synthesis

  • J Antibiot (Tokyo). 1987 Oct;40(10):1400-7. doi: 10.7164/antibiotics.40.1400.
T Namiki 1,  M Nishikawa,  Y Itoh,  I Uchida,  M Hashimoto
Affiliations

Affiliation

  • 1 Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
PMID: 3119548 DOI: 10.7164/antibiotics.40.1400
Abstract

The structure of WF-3681, a novel Aldose Reductase Inhibitor produced by Chaetomella raphigera Swift No. 3681, was deduced to be 1 on the basis of its spectroscopic and chemical evidences and confirmed by a total synthesis starting from (E)-5-phenyl-4-pentenol.

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