2. Academic Validation
  3. Ecological toxicity reduction of dinotefuran to honeybee: New perspective from an enantiomeric level

Ecological toxicity reduction of dinotefuran to honeybee: New perspective from an enantiomeric level

  • Environ Int. 2019 Sep;130:104854. doi: 10.1016/j.envint.2019.05.048.
Zenglong Chen 1,  Xiangmei Yao 2,  Fengshou Dong 3,  Hongxia Duan 4,  Xusheng Shao 5,  Xiu Chen 2,  Ting Yang 2,  Guirong Wang 6,  Yongquan Zheng 7
Affiliations

Affiliations

  • 1 State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China.
  • 2 State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China.
  • 3 State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China. Electronic address: dongfengshou@caas.cn.
  • 4 Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, PR China.
  • 5 School of Pharmacy, East China University of Science and Technology, Shanghai 200237, PR China.
  • 6 State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China. Electronic address: grwang@ippcaas.cn.
  • 7 State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China. Electronic address: zhengyongquan@ippcaas.cn.
PMID: 31200156 DOI: 10.1016/j.envint.2019.05.048
Abstract

In last decade, there has been a concerted effort to reduce the potential threats of honeybees' population due to exposure to neonicotinoid pesticides. A new perspective was put forward to reduce the potential ecological toxicity of neonicotinoid dinotefuran to honeybee in terms of an enantiomeric level in the study. Toxicity of dinotefuran was enantioselective, and S-dinotefuran was 41.1- to 128.4-fold more toxic than R-dinotefuran to honeybee Apis mellifera (Apis mellifera Linnaeus), whereas R-dinotefuran exhibited comparative insecticidal activities (1.7-2.4 times) to typical sucking pests Aphis gossypii and Apolygus lucorum compared to racemic mixtures. Our data suggested that use of R-dinotefuran could have a good efficacy in controlling target pests while minimizing hazard to honeybees. The mechanism for chiral specific toxicity to honeybee was further characterized by electrophysiological studies and molecular docking. S-dinotefuran appears to be more toxic by binding to α8 subunit of nAChR of Apis mellifera. The α8 also have a more stable, functional binding cavity to S-dinotefuran with a higher binding score of 7.15, primarily due to an extensive hydrogen bond network. Therefore, new chiral products with a high proportion of or an enantiomeric pure R-dinotefuran are recommended to achieve effective pests control reducing hazard to honeybee populations.

Keywords

Chiral neonicotinoid; Dinotefuran enantiomers; Enantioselective toxicology; Honeybee; Toxicity reduction.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z