2. Academic Validation
  3. Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β-catenin signaling

Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β-catenin signaling

  • J Cell Biochem. 2019 Oct;120(10):17273-17282. doi: 10.1002/jcb.28989.
Min-Yi Lv 1 2,  Chuan-Jian Shi 1 2,  Fei-Fei Pan 1 2,  Jiang Shao 3 4,  Lu Feng 5,  Guoqin Chen 6,  Caiwen Ou 7,  Jin-Fang Zhang 3 4,  Wei-Ming Fu 1 2
Affiliations

Affiliations

  • 1 Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
  • 2 School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
  • 3 Key Laboratory of Orthopaedics and Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
  • 4 Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
  • 5 Department of Orthopaedics and Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
  • 6 Department of Central Hospital of Panyu, Cardiovascular Medicine, Guangzhou, People's Republic of China.
  • 7 Zhujiang Hospital, Southern Medical University, Key Laboratory of Construction and Detection of Guangdong Province, Guangdong Province Center of Biomedical Engineering for Cardiovascular Diseases, No. 1023, Shatai Nan Road, Guangzhou, People's Republic of China.
PMID: 31218741 DOI: 10.1002/jcb.28989
Abstract

Consumption of dietary ellagitannins (ETs) has been proven to benefit multiple chronic health disorders including cancers and cardiovascular diseases. Urolithins, gut microbiota metabolites derived from ETs, are considered as the molecules responsible for these health effects. Previous studies have demonstrated that urolithins exhibit antiproliferative effects on prostate, breast, and colon cancers. However, as for hepatocellular carcinoma (HCC), it remains elusive. Herein, we aim to investigate the function of urolithin B (UB), a member of urolithins family, in HCC. The effects of UB on cell viability, cell cycle and Apoptosis were evaluated in HCC cells, and we found UB could inhibit the proliferation of HCC cells, which resulted from cell cycle arrest and Apoptosis. Furthermore, UB could increase phosphorylated β-catenin expression and block its translocation from nuclear to cytoplasm, thus inducing the inactivation of Wnt/β-catenin signaling. Using a xenograft mice model, UB was found to suppress tumor growth in vivo. In conclusion, our data demonstrated that UB could inhibit the proliferation of HCC cells in vitro and in vivo via inactivating Wnt/β-catenin signaling, suggesting UB could be a promising candidate in the development of Anticancer drugs targeting HCC.

Keywords

Wnt/β-catenin; apoptosis; cell cycle; hepatocellular carcinoma; urolithin B.

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