2. Academic Validation
  3. Sulfamates in drug design and discovery: Pre-clinical and clinical investigations

Sulfamates in drug design and discovery: Pre-clinical and clinical investigations

  • Eur J Med Chem. 2019 Oct 1:179:257-271. doi: 10.1016/j.ejmech.2019.06.052.
Seyed-Omar Zaraei 1,  Abduelmula R Abduelkarem 2,  Hanan S Anbar 3,  Sara Kobeissi 2,  Miami Mohammad 2,  Aya Ossama 2,  Mohammed I El-Gamal 4
Affiliations

Affiliations

  • 1 Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 27272, United Arab Emirates.
  • 2 College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates.
  • 3 Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt.
  • 4 Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 27272, United Arab Emirates; College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates; Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt. Electronic address: drmelgamal2002@gmail.com.
PMID: 31255926 DOI: 10.1016/j.ejmech.2019.06.052
Abstract

In the present article, we reviewed the sulfamate-containing compounds reported as bioactive molecules. The possible molecular targets of sulfamate derivatives include Steroid Sulfatase enzyme, carbonic anhydrases, acyl transferase, and Others. Sulfamate derivatives can help treat hormone-dependent tumors including breast, prostate, and endometrial cancers, Binge eating disorder, migraine, glaucoma, weight loss, and epilepsy. Sulfamate derivatives can act also as calcium sensing receptor agonists and can aid in osteoporosis. Furthermore, acyl sulfamate derivatives can act as Antibacterial agents against Gram-positive bacteria. A recent study revealed a new side effect of topiramate, a sulfamate-containing compound, which is sialolithiasis. The structural and biological characteristics of the reviewed compounds are presented in detail.

Keywords

Anti-cancer; Carbonic anhydrase; Irosustat; Steroid sulfatase; Sulfamate; Topiramate.

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