2. Academic Validation
  3. The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile

The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile

  • Eur J Med Chem. 2019 Nov 1:181:111579. doi: 10.1016/j.ejmech.2019.111579.
Annalisa Maruca 1,  Raffaella Catalano 1,  Donatella Bagetta 1,  Francesco Mesiti 1,  Francesca Alessandra Ambrosio 2,  Isabella Romeo 3,  Federica Moraca 4,  Roberta Rocca 5,  Francesco Ortuso 1,  Anna Artese 1,  Giosuè Costa 1,  Stefano Alcaro 1,  Antonio Lupia 1
Affiliations

Affiliations

  • 1 Dipartimento di Scienze della Salute, Università "Magna Græcia", Campus Salvatore Venuta, Viale Europa, 88100, Catanzaro, Italy; Net4Science srl, Università "Magna Græcia", Campus Salvatore Venuta, Viale Europa, 88100, Catanzaro, Italy.
  • 2 Dipartimento di Scienze della Salute, Università "Magna Græcia", Campus Salvatore Venuta, Viale Europa, 88100, Catanzaro, Italy.
  • 3 Net4Science srl, Università "Magna Græcia", Campus Salvatore Venuta, Viale Europa, 88100, Catanzaro, Italy; Department of Chemistry and Chemical Technology, University of Calabria, Via Pietro Bucci, 87036, Arcavacata di Rende, Cosenza, Italy.
  • 4 Net4Science srl, Università "Magna Græcia", Campus Salvatore Venuta, Viale Europa, 88100, Catanzaro, Italy; Department of Pharmacy, University of Naples "Federico II", Via D. Montesano, 49, 80131, Naples, Italy.
  • 5 Net4Science srl, Università "Magna Græcia", Campus Salvatore Venuta, Viale Europa, 88100, Catanzaro, Italy; Department of Experimental and Clinical Medicine "Magna Græcia" University, Campus Salvatore Venuta, Viale Europa, 88100, Catanzaro, Italy. Electronic address: rocca@unicz.it.
PMID: 31398616 DOI: 10.1016/j.ejmech.2019.111579
Abstract

Many bioactive agents have been extracted from Plants or belong to functional foods and have been considered in the treatment of serious and multifactorial diseases, such as Cancer. In particular, this review is focused on the anti-cancer properties owned by several Natural Products typically from the Mediterranean area. In some regions of the South of Italy, a lower Cancer incidence has been observed. There is increasing evidence that adherence to a Mediterranean dietary pattern correlates with reduced risk of several Cancer types. This could be mainly attributed to the typical lifestyle aspects of the Mediterranean diet, such as high consumption of fruit and vegetables. In this review, the main Natural Products of the Mediterranean area are discussed, with particular attention on their anti-cancer properties endowed with multi-target profiles.

Keywords

Anti-oxidant; Anti-proliferative; Anticancer; Mediterranean diet; Mediterranean products; Multi-target; Natural products.

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