2. Academic Validation
  3. Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones

Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones

  • Bioorg Med Chem. 2020 Feb 1;28(3):115281. doi: 10.1016/j.bmc.2019.115281.
Haoquan He 1,  Zheng Liu 2,  Wei Wang 1,  Xiaojian Jiang 3
Affiliations

Affiliations

  • 1 International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • 2 Foshan Stomatology Hospital, School of Stomatology and Medicine, Foshan University, Foshan 528000, China.
  • 3 International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: chemjxj2015@jnu.edu.cn.
PMID: 31889606 DOI: 10.1016/j.bmc.2019.115281
Abstract

α-exo-Methylene-γ-butyrolactones and α-exo-methylene-δ-valerolactones constitute an important group of natural and bioactive products. A simple and general protocol of halolactonization of dienoic acids to obtain various α-exo-methylene-lactones in excellent yields is described. The resulting halogenated α-exo-methylene-lactones were found to exhibit potent cytotoxic activities.

Keywords

Cytotoxic activity; Dienoic acid; Halolactonization; α-exo-methylene-lactones.

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