2. Academic Validation
  3. Prophylaxis of ferrets with nitazoxanide and oseltamivir combinations is more effective at reducing the impact of influenza a virus infection compared to oseltamivir monotherapy

Prophylaxis of ferrets with nitazoxanide and oseltamivir combinations is more effective at reducing the impact of influenza a virus infection compared to oseltamivir monotherapy

  • Antiviral Res. 2020 Apr;176:104751. doi: 10.1016/j.antiviral.2020.104751.
Edin J Mifsud 1,  Danielle Tilmanis 2,  Ding Yuan Oh 3,  Celeste Ming-Kay Tai 2,  Jean-Francois Rossignol 4,  Aeron C Hurt 3
Affiliations

Affiliations

  • 1 WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia. Electronic address: Edin.mifsud@influenzacentre.org.
  • 2 WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • 3 WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; School of Health and Life Sciences, Federation University, Churchill, Victoria, Australia.
  • 4 Romark Laboratories, L.C., Tampa, FL, USA.
PMID: 32088248 DOI: 10.1016/j.antiviral.2020.104751
Abstract

Combination therapy is an alternative approach to reduce viral shedding and improve clinical outcomes following Influenza Virus infections. In this study we used oseltamivir (OST), a neuraminidase inhibitor and nitazoxanide (NTZ), a host directed drug, and found in vitro that the combination of these two antivirals have a synergistic relationship. Using the ferret model of (A/Perth/265/2009, (H1N1)pdm09), virus infections, we found that the combination of NTZ and OST was more effective than either NTZ or OST independently in preventing Infection and reducing duration of viral shedding. However, these benefits were only seen if treatment was administered prophylactically, as opposed to therapeutically. We also found that if prophylactically treated ferrets that had detectable virus in the upper respiratory tract, no virus was detected in the lower respiratory tract. This benefit was not observed with NTZ or OST alone. The combination of NTZ and OST enhances the Antiviral effect of OST, which is the standard of care in most settings.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z