2. Academic Validation
  3. Curdlan stimulates tissue mast cells to synthesize pro-inflammatory mediators, generate ROS, and migrate via Dectin-1 receptor

Curdlan stimulates tissue mast cells to synthesize pro-inflammatory mediators, generate ROS, and migrate via Dectin-1 receptor

  • Cell Immunol. 2020 May:351:104079. doi: 10.1016/j.cellimm.2020.104079.
Paulina Żelechowska 1,  Sylwia Różalska 2,  Magdalena Wiktorska 3,  Ewa Brzezińska-Błaszczyk 4,  Justyna Agier 1
Affiliations

Affiliations

  • 1 Department of Experimental Immunology, Faculty of Health Sciences, Medical University of Lodz, 92-213 Lodz, Poland.
  • 2 Department of Industrial Microbiology and Biotechnology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
  • 3 Department of Molecular Cell Mechanisms, Faculty of Health Sciences, Medical University of Lodz, 92-215 Lodz, Poland.
  • 4 Department of Experimental Immunology, Faculty of Health Sciences, Medical University of Lodz, 92-213 Lodz, Poland. Electronic address: ewab@csk.umed.lodz.pl.
PMID: 32115182 DOI: 10.1016/j.cellimm.2020.104079
Abstract

Mast cells (MCs) are engaged in host defense against various pathogens as they are equipped with Pattern Recognition Receptors (PRRs). Among PRRs expressed on MCs, there are also molecules recognizing components of the Fungal cell wall, which are able to induce cellular activation and response. However, little information is available concerning the MC activation by various fungal-derived components. The aim of the study was to determine whether curdlan, a model Fungal particle of β-(1,3)-glucan, can directly stimulate tissue MCs. We demonstrated that curdlan triggers MCs to initiate pro-inflammatory response as it activates these cells to synthesize essential pro-inflammatory and/or immunoregulatory factors. We also showed that curdlan serves as a potent chemoattractant for MCs and stimulates those cells to generate Reactive Oxygen Species (ROS). Finally, we documented that curdlan induces MC response via Dectin-1. Our observations support the idea that MCs serve as important sentinels modulating immune response during fungal Infection.

Keywords

Curdlan; Host defense; Immune response; Mast cell; β-(1,3)-glucan.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z