2. Academic Validation
  3. Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim

Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim

  • J Ethnopharmacol. 2020 Jul 15:257:112787. doi: 10.1016/j.jep.2020.112787.
Hong-Yan Xu 1,  Ji-Hua Ren 1,  Yu Su 2,  Fang Ren 1,  Yu-Jiao Zhou 1,  Hui Jiang 1,  Sheng-Tao Cheng 1,  Chuan-Rui Zhang 3,  Juan Chen 4
Affiliations

Affiliations

  • 1 The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • 2 Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, and Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China.
  • 3 Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, and Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. Electronic address: crzhang@cqu.edu.cn.
  • 4 The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Electronic address: chenjuan2014@cqmu.edu.cn.
PMID: 32224198 DOI: 10.1016/j.jep.2020.112787
Abstract

Ethnopharmacological relevance: Iris tectorum Maxim (I. tectorum, Yuan Wei in Chinese) is a common and traditional Chinese medicinal herb that be used to treat liver-related diseases. However, the anti-HBV activity of I. tectorum and its isolates has not been systemically studied.

Aim of the study: To screen the active part of I. tectorum and systemically evaluate their anti-HBV activity.

Materials and methods: In this study, a series of compounds from I. tectorum were evaluated for their ability to inhibit HBV replication. Swertisin showed a significant inhibitory function on HBV replication. Then, the suppression effect of different concentrations of swertisin in HBsAg, HBeAg and HBV DNA level in HepG2.2.15 cells and HBV-infected HepG2-NTCP cells were comprehensive evaluated, respectively. Moreover, the anti-HBV effects of swertisin were confirmed in HBV transgenic mice model.

Results: Among these compounds, swertisin strongly inhibited the HBsAg, HBeAg and HBV DNA level in a dose-dependent manner in HepG2.2.15 cells and HBV-infected HepG2-NTCP cells. Furthermore, swertisin showed a significant inhibition role on HBV replication in HBV transgenic mice model, the inhibition effect of which was enhanced when combined with ETV.

Conclusions: We have identified that swertisin can inhibit HBeAg and HBsAg production, as well as HBV DNA in vitro and in vivo. This study show that we may found a novel compound isolated from traditional Chinese medicines with potent anti-HBV function.

Keywords

HBeAg; HBsAg; Hepatitis B virus; Iris tectorum Maxim; Swertisin.

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