2. Academic Validation
  3. Chemical constituents from the thorns of Gleditsia sinensis and their cytotoxic activities

Chemical constituents from the thorns of Gleditsia sinensis and their cytotoxic activities

  • J Asian Nat Prod Res. 2020 Dec;22(12):1121-1129. doi: 10.1080/10286020.2020.1731799.
Yu-Bo Zhang 1 2,  Kar-Ho Lam 1,  Li-Feng Chen 2,  Hei Wan 1,  Guo-Cai Wang 2,  Kai-Fai Lee 3,  Chun-Wang Yip 1,  Kwun-Hung Liu 1,  Pak-Heng Leung 4,  Hai-Yong Chan 1,  Yi-Gang Shi 1,  Jia Zhao 1,  Li-Xing Lao 1,  Yao-Lan Li 2,  Yan-Bo Zhang 1,  Wei Meng 1
Affiliations

Affiliations

  • 1 Yu Jin, Master of Gynaecology of Chinese Medicine & Integrative Medicine, Integrative Medicine, Integrative Medicine Workstation for Training and Research (Hong Kong Branch), School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • 2 Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • 3 Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • 4 Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
PMID: 32290704 DOI: 10.1080/10286020.2020.1731799
Abstract

A new aromatic glycoside (1) and a new natural product, neolignan (2), along with twenty-three known compounds (3-25), were isolated from the thorns of Gleditsia sinensis. According to the spectroscopic analyses (IR, UV, HRESIMS, NMR and ECD), the structures of isolates were elucidated. Herein, compounds 4, 6-8, 10-13, 15, 16, 18, 20, 23 were isolated from the plant of G. sinensis for the first time. Moreover, compounds 4, 6, 15 and 24 showed cytotoxic effects on human ovarian Cancer (SKOV-3) cells with IC50 values of 24.83 ± 4.90, 48.86 ± 9.11, 80.13 ± 5.62, 15.38 ± 2.21 μM, respectively. [Formula: see text].

Keywords

Gleditsia sinensis; Leguminosae; chemical constituent; cytotoxic activity; structural identification.

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