1. Academic Validation
  2. Cucurbitane-Type Triterpenoids from the Vines of Momordica charantia and Their Anti-inflammatory Activities

Cucurbitane-Type Triterpenoids from the Vines of Momordica charantia and Their Anti-inflammatory Activities

  • J Nat Prod. 2020 May 22;83(5):1400-1408. doi: 10.1021/acs.jnatprod.9b00592.
Hung-Tse Huang 1 Li-Jie Zhang 1 2 Hui-Chi Huang 3 Syh-Yuan Hwang 4 Chia-Lun Wu 5 Yu-Chi Lin 1 Chia-Ching Liaw 1 6 Yung-Yi Cheng 7 8 Susan L Morris-Natschke 7 8 Chung-Yi Huang 5 Kuo-Hsiung Lee 7 8 Yao-Haur Kuo 1 9
Affiliations

Affiliations

  • 1 Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
  • 2 Institute of Pharmaceutics, Development Center Biotechnology, New Taipei City 221, Taiwan.
  • 3 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.
  • 4 Endemic Species Research Institute, Council of Agriculture, Nantou 552, Taiwan.
  • 5 Department of Food Science, National Ilan University, Ilan 260, Taiwan.
  • 6 Department of Research and Development, Starsci Biotech Co. Ltd., Taipei 112, Taiwan.
  • 7 Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, United States.
  • 8 Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 404, Taiwan.
  • 9 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Abstract

Seven new cucurbitane-type triterpenoids, kuguaovins A-G (1-7), and five known ones were isolated from the rattans of wild Momordica charantia. Their structures were established by spectroscopic data analyses, including 1D and 2D NMR, IR, and MS techniques. The absolute configurations of the cucurbitanes were determined from NOESY data and partially by X-ray crystallographic analysis. In pharmacological studies, compounds 1-7 and 9-12 exhibited weak anti-inflammatory effects (IC50 = 15-35 μM), based on an anti-NO production assay.

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