2. Academic Validation
  3. Asiaticoside attenuates bleomycin-induced pulmonary fibrosis in A2aR-/- mice by promoting the BMP7/Smad1/5 signaling pathway

Asiaticoside attenuates bleomycin-induced pulmonary fibrosis in A2aR-/- mice by promoting the BMP7/Smad1/5 signaling pathway

  • Biochem Biophys Res Commun. 2020 Jun 30;527(3):662-667. doi: 10.1016/j.bbrc.2020.04.156.
Ting Zhang 1,  Jianyi Dai 2,  Wenjing Ye 3,  Luqiong Cai 4,  Jinqiu Wei 4,  Mayun Chen 4,  Xiaoying Huang 5,  Xiaobing Wang 6
Affiliations

Affiliations

  • 1 Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Wenling, Zhejiang, China.
  • 2 Department of Cardiology, The People's Hospital of Yuhuan, Zhejiang, China.
  • 3 Division of Rheumatology and Immunology, Huashan Hospital, Fudan University, Shanghai, China.
  • 4 Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
  • 5 Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. Electronic address: zjwzhxy@126.com.
  • 6 Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. Electronic address: gale820907@163.com.
PMID: 32423816 DOI: 10.1016/j.bbrc.2020.04.156
Abstract

Idiopathic Pulmonary fibrosis(PF)is a chronic progressive disease, which is a lack of effective treatment,and the pathogenesis of IPF is not fully elucidated. Asiaticoside(AS) is isolated from Centella asiatica and has the effect of promoting scar healing and reducing scar formation. However,its possible role in idiopathic pulmonary fibrosis remains unclear. Adenosine A2A receptor (A2AR) is reported a protective factor in pulmonary fibrosis, and the bone morphogenetic protein 7 (BMP7) signaling pathway plays a crucial role in fibrosis in multiple organs. But the impact of A2AR on the BMP7 pathway has not yet been reported. Therefore, we hypothesized AS may promote the expression of A2AR, and then influence the BMP7/Smad1/5 pathway to alleviate pulmonary fibrosis. A2AR-/- mice and wild-type (WT) mice were administered bleomycin (BLM) by intratracheal injection. AS (50 mg/kg/d) was given daily for 28 days. AS reduced collagen deposition in lung tissue, interstitial lung inflammation. Furthermore, AS promoted A2AR expression and BMP7 pathway. Collectively, AS may attenuate BLM-induced pulmonary fibrosis by upregulating the BMP7 signaling pathway through A2AR.

Keywords

Adenosine 2A receptor; Asiaticoside; Bleomycin; Bone morphogenetic protein 7; Pulmonary fibrosis; Smad1/5.

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