2. Academic Validation
  3. Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats

Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats

  • J Ethnopharmacol. 2020 Oct 28:261:113054. doi: 10.1016/j.jep.2020.113054.
Le Kang 1,  Jin-Xin Miao 2,  Li-Hua Cao 3,  Yan-Yan Miao 4,  Ming-San Miao 5,  Hui-Juan Liu 6,  Li-Ling Xiang 7,  Ya-Gang Song 8
Affiliations

Affiliations

  • 1 National International Cooperation Base of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: kangle56@outlook.com.
  • 2 Immunopharmacology Laboratory of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: jinxin.miao@yahoo.com.
  • 3 Immunopharmacology Laboratory of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: caolihua727@126.com.
  • 4 College of Basic Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: yanyanmiao@139.com.
  • 5 National International Cooperation Base of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: miaomingsan@hactcm.edu.cn.
  • 6 National International Cooperation Base of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: liuhuijuan_n@126.com.
  • 7 National International Cooperation Base of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: xiangliling168@163.com.
  • 8 National International Cooperation Base of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: songyagang1016@163.com.
PMID: 32534113 DOI: 10.1016/j.jep.2020.113054
Abstract

Ethnopharmacological relevance: Herbaceous peony (Paeonia lactiflora Pall.) flower has been used widely in dietotherapy in China and other countries. It has good ethnopharmacological value in the treatment of various metabolic diseases. However, the molecular mechanisms by which it lowers serum uric acid are unknown. The development of pharmaceutical resources is very important. Here, we sought to elucidate the mode of action of herbaceous peony in terms of reducing uric acid levels.

Aim of the study: In the present research, the effects of the total glucosides of herbaceous peony flower were investigated in a rat hyperuricaemia model. Another aim of the study was to clarify the mechanism by which herbaceous peony flower (TGPF) lowers serum uric acid levels.

Materials and methods: A hyperuricaemic rat model was induced via intragastric administration of 100 mg/kg adenine and 250 mg/kg ethambutol hydrochloride (EH) for 23 d. Then TongFengShu 600 mg/kg, allopurinol 42 mg/kg, or TGPF (50 mg/kg, 100 mg/kg, or 200 mg/kg) was administered 1 h after the adenine and EH treatments.

Results: TGPF improved weight loss and decreased serum UA, XOD, MCP-1, TNF-α, Cr, and BUN in the rats with hyperuricaemic nephropathy. TGPF downregulated renal URAT1 and GLUT9, upregulated renal OAT1, and ameliorated histopathological changes in the thymus, spleen, and kidney.

Conclusion: TGPF is promising as a therapeutic agent against hyperuricaemia. It regulates the uric acid transporters and diminished serum uric acid levels, and alleviates renal pathology associated with hyperuricaemia.

Keywords

Arthritis; Gout; Hyperuricaemia; Paeonia albiflora Pall; Renal pharmacology; Traditional Chinese medicine.

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