2. Academic Validation
  3. Proversilins A-E, Drimane-Type Sesquiterpenoids from the Endophytic Aspergillus versicolor

Proversilins A-E, Drimane-Type Sesquiterpenoids from the Endophytic Aspergillus versicolor

  • J Nat Prod. 2020 Jul 24;83(7):2200-2206. doi: 10.1021/acs.jnatprod.0c00298.
Huaqiang Li 1,  Runge Zhang 1,  Fei Cao 2,  Jianping Wang 1,  Zhengxi Hu 1,  Yonghui Zhang 1
Affiliations

Affiliations

  • 1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • 2 College of Pharmaceutical Sciences, Hebei University, Baoding 071002, People's Republic of China.
PMID: 32628478 DOI: 10.1021/acs.jnatprod.0c00298
Abstract

Five new drimane-type sesquiterpenoids, named proversilins A-E (1-5), were isolated from the endophytic fungus Aspergillus versicolor F210 isolated from the bulbs of Lycoris radiata. Their structures and absolute configurations were characterized by extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS data, comparison of experimental and calculated electronic circular dichroism data, and X-ray crystallography. Proversilins B-E (2-5) represent the first examples of Natural Products featuring an N-acetyl-β-phenylalanine moiety. Compounds 3 and 5 inhibited the growth of HL-60 cells with IC50 values of 7.3 and 9.9 μM, respectively.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z