2. Academic Validation
  3. An insight on medicinal attributes of 1,2,4-triazoles

An insight on medicinal attributes of 1,2,4-triazoles

  • Eur J Med Chem. 2020 Nov 1:205:112652. doi: 10.1016/j.ejmech.2020.112652.
Ranjana Aggarwal 1,  Garima Sumran 2
Affiliations

Affiliations

  • 1 Department of Chemistry, Kurukshetra University, Kurukshetra, 136 119, India; CSIR-National Institute of Science Technology and Development Studies, New Delhi, India. Electronic address: ranjana67in@yahoo.com.
  • 2 Department of Chemistry, D. A. V. College (Lahore), Ambala City, 134 003, Haryana, India. Electronic address: garimasumran@gmail.com.
PMID: 32771798 DOI: 10.1016/j.ejmech.2020.112652
Abstract

The present review aims to summarize the pharmacological profile of 1,2,4-triazole, one of the emerging privileged scaffold, as Antifungal, Antibacterial, Anticancer, anticonvulsant, antituberculosis, Antiviral, antiparasitic, analgesic and anti-inflammatory agents, etc. along with structure-activity relationship. The comprehensive compilation of work carried out in the last decade on 1,2,4-triazole nucleus will provide inevitable scope for researchers for the advancement of novel potential drug candidates having better efficacy and selectivity.

Keywords

1,2,4-Triazole; Enzyme inhibitors; Hybrid compounds; Molecular interactions; Pharmacological activities; Structure-activity relationship.

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