2. Academic Validation
  3. Exposure to formaldehyde at low temperatures aggravates allergic asthma involved in transient receptor potential ion channel

Exposure to formaldehyde at low temperatures aggravates allergic asthma involved in transient receptor potential ion channel

  • Environ Toxicol Pharmacol. 2020 Nov;80:103469. doi: 10.1016/j.etap.2020.103469.
Yuxin Wu 1,  Jiufei Duan 2,  Baizhan Li 1,  Hong Liu 3,  Mingqing Chen 4
Affiliations

Affiliations

  • 1 Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, China; National Centre for International Research of Low-Carbon and Green Buildings (Ministry of Science and Technology), Chongqing University, Chongqing 400045, China.
  • 2 Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China.
  • 3 Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, China; National Centre for International Research of Low-Carbon and Green Buildings (Ministry of Science and Technology), Chongqing University, Chongqing 400045, China. Electronic address: liuhong1865@163.com.
  • 4 Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China. Electronic address: chenmq@mail.ccnu.edu.cn.
PMID: 32798733 DOI: 10.1016/j.etap.2020.103469
Abstract

Studies have indicated that formaldehyde and low temperature are considered to be the factors associated with several respiratory diseases. However, the effect of co-exposure to formaldehyde and low temperature on allergic asthma, and the potential mechanisms, are unknown. In this study, an allergic asthma mouse model was built and mice were exposed to 0.8 mg/m3 formaldehyde and/or subjected to low temperatures of 16 °C. The data showed that exposure to either low temperature or formaldehyde did not induce a significant aggravation on allergic asthma. However, simultaneous exposure to formaldehyde and low temperature was shown to aggravate mucus hypersecretion and inflammation in the lung, lead to an exacerbation of allergic asthma. After blocking the TRPM8 and TRPA1 ion channels, the levels of inflammatory factors reduced. These results demonstrated that co-exposure to formaldehyde and low temperature exacerbate allergic asthma, and that TRPM8 and TRPA1 are involved in this process.

Keywords

Allergic asthma; Formaldehyde; Low temperature; TRPA1; TRPM8.

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