2. Academic Validation
  3. The Kv1.3 ion channel acts as a host factor restricting viral entry

The Kv1.3 ion channel acts as a host factor restricting viral entry

  • FASEB J. 2021 Feb;35(2):e20995. doi: 10.1096/fj.202000879RR.
Yange Lang 1,  Fangfang Li 1,  Qiang Liu 2,  Zhiqiang Xia 1,  Zhenglin Ji 1,  Juan Hu 2,  Yuting Cheng 1,  Minjun Gao 1,  Fang Sun 1,  Bingzheng Shen 1,  Chang Xie 2,  Wei Yi 3,  Yingliang Wu 1 4,  Jing Yao 2,  Zhijian Cao 1 4 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, P.R. China.
  • 2 State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, P.R. China.
  • 3 Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, P.R. China.
  • 4 Bio-drug Research Center, Wuhan University, Wuhan, P. R. China.
  • 5 Hubei Province Engineering and Technology Research, Center for Fluorinated Pharmaceuticals, Wuhan University, Wuhan, P.R. China.
PMID: 32910509 DOI: 10.1096/fj.202000879RR
Abstract

Virus entry into cells is the initial stage of Infection and involves multiple steps, and interfering viral entry represents potential Antiviral approaches. Ion channels are pore-forming membrane proteins controlling cellular ion homeostasis and regulating many physiological processes, but their roles during viral Infection have rarely been explored. Here, the functional Kv1.3 ion channel was found to be expressed in human hepatic cells and tissues. The Kv1.3 was then revealed to restrict HCV entry via inhibiting endosome acidification-mediated viral membrane fusion. The Kv1.3 was also demonstrated to inhibit DENV and ZIKV with an endosome acidification-dependent entry, but have no effect on SeV with a neutral pH penetration. A Kv1.3 antagonist PAP-1 treatment accelerated animal death in ZIKV-infected IFNAR1-/- mice. Moreover, Kv1.3-deletion was found to promote weight loss and reduce survival rate in ZIKV-infected Kv1.3-/- mice. Altogether, the Kv1.3 ion channel behaves as a host factor restricting viral entry. These findings broaden understanding about ion channel biology.

Keywords

Dengue virus; Kv1.3 ion channel; Zika virus; hepatitis C virus; host factor.

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