2. Academic Validation
  3. Syringoleosides A-H, Secoiridoids from Syringa dilatata Flowers and Their Inhibition of NO Production in LPS-Induced RAW 264.7 Cells

Syringoleosides A-H, Secoiridoids from Syringa dilatata Flowers and Their Inhibition of NO Production in LPS-Induced RAW 264.7 Cells

  • J Nat Prod. 2020 Sep 25;83(9):2655-2663. doi: 10.1021/acs.jnatprod.0c00490.
Jung Eun Gwag 1,  Yeong-Geun Lee 1,  Hyoung-Geun Kim 1,  Dong-Sung Lee 2,  Dae Young Lee 3,  Nam-In Baek 1
Affiliations

Affiliations

  • 1 Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea.
  • 2 College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
  • 3 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 27709, Republic of Korea.
PMID: 32936639 DOI: 10.1021/acs.jnatprod.0c00490
Abstract

Repeated column chromatography of Syringa dilatata flowers, a native shrub to Korea, led to the isolation of eight new oleoside-type secoiridoids, syringoleosides A-H (1-8), as well as five known secoiridoids (9-13). The new chemical structures were identified through spectroscopic data analysis, as well as the application of chemical methods. Compounds 1, 2, 6, 7, 11, and 13 showed suppression effects on NO production in LPS-induced RAW 264.7 cells, with IC50 values ranging from 32.5 ± 9.8 to 65.7 ± 11.0 μM, and no visible toxicity. The content of the major secoiridoids in S. dilatata flowers, compounds 1, 4, 5, 8, 9, 12, and 13, were determined through HPLC analysis.

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