2. Academic Validation
  3. Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules

Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules

  • Eur J Med Chem. 2021 Jan 1:209:112946. doi: 10.1016/j.ejmech.2020.112946.
Zhang-Xu He 1,  Yun-Peng Gong 1,  Xin Zhang 1,  Li-Ying Ma 2,  Wen Zhao 3
Affiliations

Affiliations

  • 1 Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, PR China.
  • 2 Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, PR China. Electronic address: maliying@zzu.edu.cn.
  • 3 Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, PR China. Electronic address: zhaowen100@139.com.
PMID: 33129590 DOI: 10.1016/j.ejmech.2020.112946
Abstract

Identification of potent Anticancer agents with high selectivity and low toxicity remains on the way to human health. Pyridazine featuring advantageous physicochemical properties and antitumor potential usually is regarded as a central core in numerous Anticancer derivatives. There are several approved pyridazine-based drugs in the market and analogues currently going through different clinical phases or registration statuses, suggesting pyridazine as a promising drug-like scaffold. The current review is intended to provide a comprehensive and updated overview of pyridazine derivatives as potential Anticancer agents. In particular, we focused on their structure-activity relationship (SAR) studies, design strategies, binding modes and biological activities in the hope of offering novel insights for further rational design of more active and less toxic Anticancer drugs.

Keywords

Anticancer; Drug-like scaffold; Pyridazine; SAR.

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