2. Academic Validation
  3. Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri

Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri

  • J Nat Prod. 2020 Dec 24;83(12):3681-3688. doi: 10.1021/acs.jnatprod.0c00901.
Yue Yang 1 2,  Qi Gong 3,  Wei Wang 3,  Ying-Le Mao 1,  Xiao-Rong Wang 4,  Sheng Yao 1,  Hai-Yan Zhang 3,  Chunping Tang 1,  Yang Ye 1 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
  • 2 University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
  • 3 CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
  • 4 Xishuangbanna Research Institute of Nationality Medicine, & Xishuangbanna Hospital of Traditional Dai Medicine, No. 8, Zhuangdong Western Road of Xishuangbanna Tourism and Resort Zone, Xishuangbanna Dai Autonomous Prefecture of Yunnan Province 666100, People's Republic of China.
  • 5 School of Life Science and Technology, ShanghaiTech University, Shanghai 201203, People's Republic of China.
PMID: 33253561 DOI: 10.1021/acs.jnatprod.0c00901
Abstract

Three new dimeric diarylheptanoids, taccachanfurans A-C (1-3), a new monomeric diarylheptanoid, taccachannoid A (4), and four known diarylheptanoids (5-8) were isolated from the EtOH extract of the rhizomes of Tacca chantrieri. Their structures were established on the basis of comprehensive spectroscopic data analysis. The absolute configuration of taccachanfuran A (1) was confirmed by single-crystal X-ray diffraction. All the diarylheptanoid dimers contain a ditetrahydrofuran moiety, which has not been described previously for diarylheptanoid compounds. A plausible biosynthetic pathway for the diarylheptanoid dimers is proposed. Compounds 2-4 showed significant neuroprotective activity against Aβ25-35-induced damage in SH-SY5Y cells at the concentrations of 10 and 1 μM. Compounds 3, 4, 6, 7, and 8 showed anti-inflammatory activity in LPS-stimulated murine microglial BV-2 cells at the concentrations of 10 and 1 μM.

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