2. Academic Validation
  3. Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents

Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents

  • RSC Med Chem. 2020 Jan 29;11(3):327-348. doi: 10.1039/c9md00458k.
M Shaheer Malik 1 2,  Saleh A Ahmed 1 2 3,  Ismail I Althagafi 1 2,  Mohammed Azam Ansari 4,  Ahmed Kamal 5
Affiliations

Affiliations

  • 1 Department of Chemistry , Faculty of Applied Sciences , Umm Al-Qura University , 21955 Makkah , Saudi Arabia . Email: msmalik@uqu.edu.sa ; Email: mdshaheermalik@gmail.com.
  • 2 Central Research Laboratories , Faculty of Applied Sciences , Umm Al-Qura University , 21955 Makkah , Saudi Arabia.
  • 3 Chemistry Department , Faculty of Science , Assiut University , 71516 Assiut , Egypt.
  • 4 Department of Epidemic Disease Research , Institute of Research and Medical Consultation , Imam AbdurRahman Bin Faisal University , 34212 Dammam , Saudi Arabia.
  • 5 School of Pharmaceutical Education and Research (SPER) , Jamia Hamdard , New Delhi-110062 , India . Email: pvc@jamiahamdard.ac.in ; Email: ahmedkamal@iict.res.in ; Tel: +91 11 26059665.
PMID: 33479639 DOI: 10.1039/c9md00458k
Abstract

The triazole ring system has emerged as an exciting prospect in the optimization studies of promising lead molecules in the quest for new drugs for clinical usage. Several marketed drugs possess these versatile moieties that are used in a wide range of medical indications. This stems from the unique intrinsic properties of triazoles, which impart stability to the basic pharmacophoric unit with an added advantage of being a bioisostere of different chemical functionalities. In the last decade, the use of triazoles as bioisosteres and linkers in the development of microtubule targeting agents has been extensively investigated. The present review highlights the advances in this promising area of drug discovery and development.

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