2. Academic Validation
  3. Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis

Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis

  • Front Pharmacol. 2021 Jan 11:11:613780. doi: 10.3389/fphar.2020.613780.
Anastasia V Poznyak 1,  Nikita G Nikiforov 2 3 4 5,  Alexander M Markin 4,  Dmitry A Kashirskikh 4,  Veronika A Myasoedova 5 6,  Elena V Gerasimova 7,  Alexander N Orekhov 1 4 5
Affiliations

Affiliations

  • 1 Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russia.
  • 2 Centre of Collective Usage, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
  • 3 National Medical Research Center of Cardiology, Institute of Experimental Cardiology, Moscow, Russia.
  • 4 Laboratory of Cellular and Molecular Pathology of the Cardiovascular System, Institute of Human Morphology, Moscow, Russia.
  • 5 Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia.
  • 6 Centro Cardiologico Monzino, Istituti di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
  • 7 Department of Systemic Rheumatic Diseases, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
PMID: 33510639 DOI: 10.3389/fphar.2020.613780
Abstract

Cardiovascular pathologies maintain the leading position in mortality worldwide. Atherosclerosis is a chronic disease that can result in a variety of serious complications, such as myocardial infarction, stroke, and Cardiovascular Disease. Inflammation and lipid metabolism alterations play a crucial role in atherogenesis, but the details of relationships and causality of these fundamental processes remain not clear. The oxidation of LDL was considered the main atherogenic modification of LDL within the vascular wall for decades. However, recent investigations provided a growing body of evidence in support of the multiple LDL modification theory. It suggests that LDL particles undergo numerous modifications that change their size, density, and chemical properties within the blood flow and vascular wall. Oxidation is the last stage in this cascade resulting in the atherogenic properties. Moreover, recent investigations have discovered that oxLDL may have both anti-inflammatory and pro-inflammatory properties. Oxidized LDL can trigger inflammation through the activation of macrophages and other cells. After all, oxidized LDL is still a promising object for further investigations that have the potential to clarify the unknown parts of the atherogenic process. In this review, we discuss the role of oxLDL in atherosclerosis development on different levels.

Keywords

atherosclerosis; cardiovascular disease; low-density lipoprotein; oxLDL; oxidative stress.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z