2. Academic Validation
  3. Cytotoxic and Anti-Inflammatory Sesquiterpenes from the Whole Plants of Centipeda minima

Cytotoxic and Anti-Inflammatory Sesquiterpenes from the Whole Plants of Centipeda minima

  • J Nat Prod. 2021 Feb 26;84(2):247-258. doi: 10.1021/acs.jnatprod.0c00884.
Peng-Hui Xue 1,  Nan Zhang 1,  Da Liu 2,  Qing-Ran Zhang 3,  Jing-Shi Duan 2,  Ya-Qin Yu 1,  Jin-Yan Li 1,  Shi-Jie Cao 1,  Feng Zhao 3,  Ning Kang 2,  Feng Qiu 1
Affiliations

Affiliations

  • 1 School of Chinese Materia Medica and State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, People's Republic of China.
  • 2 School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, People's Republic of China.
  • 3 School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, People's Republic of China.
PMID: 33533247 DOI: 10.1021/acs.jnatprod.0c00884
Abstract

Sixteen new sesquiterpene lactones (1-16) along with 13 known analogues (17-29) were isolated from the whole Plants of Centipeda minima. The structures of 1-16 were delineated by the combination of NMR spectroscopic experiments, HRESIMS, single-crystal X-ray diffraction analyses, and ECD spectra. Compounds 23-26 showed potent cytotoxicity against Hela, HCT-116, and HepG2 cells with IC50 values of 0.8-2.6, 0.4-3.3, and 1.1-2.6 μM, respectively. Compounds 8, 15, and 24 exhibited significant inhibitory activity on the production of nitric oxide in the lipopolysaccharide-activated RAW 264.7 mouse macrophage cell line, with IC50 values ranging from 0.1 to 0.2 μM.

Figures
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验，部分功能也使用 Cookies 帮助我们更好地理解您的需求，为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问，请阅读我们的《隐私声明》。

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z