2. Academic Validation
  3. Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment

Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment

  • Trends Cancer. 2021 Jun;7(6):484-487. doi: 10.1016/j.trecan.2021.01.013.
Tatiana A Mishchenko 1,  Irina V Balalaeva 1,  Maria V Vedunova 1,  Dmitri V Krysko 2
Affiliations

Affiliations

  • 1 Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation.
  • 2 Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation; Cell Death Investigation and Therapy (CDIT) Laboratory, Department of Human Structure and Repair, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium. Electronic address: dmitri.krysko@ugent.be.
PMID: 33640304 DOI: 10.1016/j.trecan.2021.01.013
Abstract

Photodynamic therapy (PDT) is widely used in Cancer treatment; however, several challenges compromise its efficiency. We propose a synergistic action between PDT and ferroptotic cell death. PDT acts as a source of Reactive Oxygen Species for the Fenton reaction, which may reinforce Ferroptosis induction and increase PDT efficacy in Anticancer therapy.

Keywords

cancer therapy; ferroptosis; immunogenic cell death; immunotherapy; photosensitizes.

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