2. Academic Validation
  3. Cytotoxic and Antiangiogenetic Xanthones Inhibiting Tumor Proliferation and Metastasis from Garcinia xipshuanbannaensis

Cytotoxic and Antiangiogenetic Xanthones Inhibiting Tumor Proliferation and Metastasis from Garcinia xipshuanbannaensis

  • J Nat Prod. 2021 May 28;84(5):1515-1523. doi: 10.1021/acs.jnatprod.0c01354.
Xuke Zhang 1,  Ziteng Song 1,  Ying Li 1,  Huimei Wang 1,  Shaojie Zhang 1,  Anna-Mari Reid 2,  Namrita Lall 2,  Jie Zhang 3,  Chunyan Wang 4,  Dongho Lee 5,  Yasushi Ohizumi 6,  Jing Xu 1,  Yuanqiang Guo 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
  • 2 Department of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa.
  • 3 Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, People's Republic of China.
  • 4 Tianjin Second People's Hospital, Tianjin 300192, People's Republic of China.
  • 5 College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
  • 6 Kansei Fukushi Research Institute, Tohoku Fukushi University, 6-149-1 Kunimigaoka, Aoba-ku, Sendai 989-3201, Japan.
PMID: 33905250 DOI: 10.1021/acs.jnatprod.0c01354
Abstract

Eight prenylated Xanthones including four new analogues were extracted and purified from the leaves of Garcinia xipshuanbannaensis. Multiple techniques including UV, 1D and 2D NMR, and HRESIMS were used to determine the structures of the isolated Xanthones. These Xanthones were evaluated for their cytotoxicity toward human Cancer cells, and compound 4 exhibited activity against HeLa cells. A cytotoxic mechanism examination revealed the active compound induced cell Apoptosis by arresting the cell cycle, increasing the levels of ROS, and inhibiting the expression of p-STAT3 in HeLa cells. In in vivo zebrafish experiments, compound 4 was found to block tumor proliferation and migration and have antiangiogenetic activity, and thus seems worthy of further laboratory evaluation.

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