2. Academic Validation
  3. Recent advances of quinones as a privileged structure in drug discovery

Recent advances of quinones as a privileged structure in drug discovery

  • Eur J Med Chem. 2021 Nov 5:223:113632. doi: 10.1016/j.ejmech.2021.113632.
Li Zhang 1,  Guiying Zhang 2,  Shujing Xu 3,  Yuning Song 4
Affiliations

Affiliations

  • 1 Department of Pharmacy, Jinan Second People's Hospital, 250001, 148 Jingyi Road, Jinan, PR China.
  • 2 Department of Pharmacy, Rizhao People's Hospital, 276800, 126 Tai'an Road, Rizhao, PR China.
  • 3 Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, PR China.
  • 4 Department of Clinical Pharmacy, Qilu Hospital of Shandong University, 250012, Jinan, PR China. Electronic address: syncat827@163.com.
PMID: 34153576 DOI: 10.1016/j.ejmech.2021.113632
Abstract

Privileged structures are conductive to discover novel bioactive substances because they can bind to multiple targets with high affinity. Quinones are considered to be a privileged structure and useful template for the design of new compounds with potential pharmacological activity. This article presents the recent developments (2014-2021 update) of Quinones in the fields of antitumor, Antibacterial, Antifungal, Antiviral, anti-Alzheimer's disease (AD) and antimalarial, mainly focusing on biological activities, structural modification and mechanism of action.

Keywords

Biological activities; Mechanism of action; Privileged structure; Quinones; Structural modification.

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