2. Academic Validation
  3. Polyketides with Anti-neuroinflammatory Activity from Theissenia cinerea

Polyketides with Anti-neuroinflammatory Activity from Theissenia cinerea

  • J Nat Prod. 2021 Jul 23;84(7):1898-1903. doi: 10.1021/acs.jnatprod.0c01307.
Meng-Hsuan Hsieh 1,  George Hsiao 2 3,  Chia-Hao Chang 1,  Yu-Liang Yang 4,  Yu-Ming Ju 5,  Yueh-Hsiung Kuo 6 7 8,  Tzong-Huei Lee 1
Affiliations

Affiliations

  • 1 Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan.
  • 2 Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
  • 3 Department of Pharmacology, School of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
  • 4 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • 5 Institute of Plant and Microbial Biology, Academia Sinica, Taipei 11529, Taiwan.
  • 6 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40447, Taiwan.
  • 7 Department of Biotechnology, Asia University, Taichung 41354, Taiwan.
  • 8 Chinese Medical Research Center, China Medical University, Taichung 40447, Taiwan.
PMID: 34185528 DOI: 10.1021/acs.jnatprod.0c01307
Abstract

Theissenia cinerea 89091602 is a previously reported plant-derived bioactive Fungal strain, and the active principles separated from the extracts of its submerged culture were shown to exhibit potent anti-neuroinflammatory activities in both cellular study and animal testing. In a continuation of our previous investigation on the bioactive entities from this fungus, solid state fermentation was performed in an attempt to diversify the bioactive secondary metabolites. In the present study, five previously unreported polyketides, theissenophenol (1), theissenepoxide (2), theissenolactone D (3), theissenone (4), and theissenisochromanone (5), together with the known theissenolactone B (6), theissenolactone C (7), and arthrinone (8), were isolated and characterized through spectroscopic analysis and comparison with the literature data. The configurations of theissenepoxide (2) and theissenisochromanone (5) were further corroborated by single-crystal X-ray diffraction data analysis. Theissenone (4), theissenolactone B (6), theissenolactone C (7), and arthrinone (8) exhibited potent nitric oxide production inhibitory activities in murine brain microglial BV-2 cells with IC50 values of 5.0 ± 1.0, 4.5 ± 0.6, 1.1 ± 0.1, and 3.2 ± 0.3 μM, respectively, without any significant cytotoxic effects.

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