2. Academic Validation
  3. Vomifoliol isolated from mangrove plant Ceriops tagal inhibits the NFAT signaling pathway with CN as the target enzyme in vitro

Vomifoliol isolated from mangrove plant Ceriops tagal inhibits the NFAT signaling pathway with CN as the target enzyme in vitro

  • Bioorg Med Chem Lett. 2021 Sep 15:48:128235. doi: 10.1016/j.bmcl.2021.128235.
Xuexia Zhang 1,  Gang Li 1,  Qin Deng 2,  Zhiyong Xu 3,  Juren Cen 4,  Jing Xu 5
Affiliations

Affiliations

  • 1 Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, PR China.
  • 2 College of Horticulture and Landscape, Hainan University, Haikou 570228, PR China.
  • 3 School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, PR China.
  • 4 School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, PR China. Electronic address: cenjr@hainanu.edu.cn.
  • 5 Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, PR China. Electronic address: happyjing3@hainanu.edu.cn.
PMID: 34216746 DOI: 10.1016/j.bmcl.2021.128235
Abstract

Vomifoliol, a natural sesquiterpene compound, is a secondary metabolite isolated from the mangrove plant Ceriops tagal. The present study aimed to determine the immunosuppressive effects and underlying mechanisms of vomifoliol on Jurkat cells in vitro. The results show that vomifoliol significantly inhibited Calcineurin (CN) at concentrations resulting in relatively low cytotoxicity. Moreover, vomifoliol was found to exert an inhibitory effect on phorbol 12-myristate 13-acetate (PMA)/ ionomycin (Io) -induced Jurkat cells and the dephosphorylation of NFAT1. In addition, it reduced the expression of IL-2. Based on these results, we concluded that vomifoliol may inhibit the immune response of Jurkat cells, and vomifoliol may use CN as the target Enzyme to inhibit NFAT signaling pathway. Therefore, vomifoliol may be promising as a low-toxic natural immunosuppressant.

Keywords

Calcineurin; Ceriops tagal; IL-2; Immunosuppressive activity; NFAT1; Vomifoliol.

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