2. Academic Validation
  3. Piezo1-Mediated Mechanotransduction Promotes Cardiac Hypertrophy by Impairing Calcium Homeostasis to Activate Calpain/Calcineurin Signaling

Piezo1-Mediated Mechanotransduction Promotes Cardiac Hypertrophy by Impairing Calcium Homeostasis to Activate Calpain/Calcineurin Signaling

  • Hypertension. 2021 Sep;78(3):647-660. doi: 10.1161/HYPERTENSIONAHA.121.17177.
Yuhao Zhang  # 1,  Sheng-An Su  # 1,  Wudi Li 1,  Yuankun Ma 1,  Jian Shen 1,  Yaping Wang 2,  Yimin Shen 1,  Jian Chen 1,  Yongli Ji 1,  Yao Xie 1,  Hong Ma 1,  Meixiang Xiang 1
Affiliations

Affiliations

  • 1 From the Department of Cardiology (Y.Z., S.-a.S., W.L., Y.M., J.S., Y.S., J.C., Y.J., Y.X., H.M., M.X.), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • 2 Department of Endocrinology (Y.W.), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • # Contributed equally.
PMID: 34333987 DOI: 10.1161/HYPERTENSIONAHA.121.17177
Abstract

[Figure: see text].

Keywords

calcineurin; calpain; fibrosis; homeostasis; mechanotransduction.

Figures
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