2. Academic Validation
  3. Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus

Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus

  • J Nat Prod. 2021 Aug 27;84(8):2272-2281. doi: 10.1021/acs.jnatprod.1c00374.
Zi-Yang Chan 1,  Premanand Krishnan 1,  Sayed Mohammadhossein Modaresi 1,  Ling-Wei Hii,  Chun-Wai Mai 2,  Wei-Meng Lim,  Chee-Onn Leong,  Yun-Yee Low 3,  Soon-Kit Wong 3,  Kien-Thai Yong 4,  Alyssa Zi-Xin Leong 1,  Mei-Kee Lee 1,  Kang-Nee Ting 1,  Kuan-Hon Lim 1
Affiliations

Affiliations

  • 1 School of Pharmacy, University of Nottingham Malaysia, Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
  • 2 State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
  • 3 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • 4 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
PMID: 34342431 DOI: 10.1021/acs.jnatprod.1c00374
Abstract

Seven new Tropane Alkaloids, including five monomeric (1-5), one dimeric (6), and one trimeric (7) 3α-nortropane ester, along with two known monomeric nortropane Alkaloids (8 and 9), were isolated from the leaves and bark of Pellacalyx saccardianus. Their structures, including the absolute configuration of the enantiomeric pair of (±)-6, were elucidated by comprehensive spectroscopic analyses. Alkaloids 6 and 7 showed cytotoxicity toward human pancreatic Cancer cell lines (AsPC-1, BxPC3, PANC-1, and SW1990). Alkaloids 1, 4, and 9 induced a smooth muscle relaxation effect comparable to that of atropine (Emax 106.1 ± 7.5%, 97.0 ± 5.2%, 100.9 ± 1.4%, 111.7 ± 1.7%, respectively) on isolated rat tracheal rings.

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